Summary of
JCBFM, November 2008.
You can find all the JCBFM summaries in web
format at our website:
A pretty thin month. All articles are
listed. My Immediate Relevance assessment is entirely implicit and is
designated with regard to work we are doing or contemplating RIGHT NOW. The Immediate
Relevance of an article might change in the future. Those papers with Immediate
Relevance rated LOW or VERY LOW do not get a Sullysummary.
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*1. Microthrombosis
after aneurysmal subarachnoid hemorrhage: an additional explanation for delayed
cerebral ischemia
Mervyn DI Vergouwen
et al.
Immediate
Relevance: VERY LOW
Link
(PDF):
http://www.nature.com/jcbfm/journal/v28/n11/pdf/jcbfm200874a.pdf
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*2. Transcriptomic
screening of microvascular endothelial cells implicates novel molecular
regulators of vascular dysfunction after spinal cord injury. Richard L
Benton et al.
Immediate Relevance: VERY LOW
Link (PDF): http://www.nature.com/jcbfm/journal/v28/n11/pdf/jcbfm200876a.pdf
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*3. Progesterone
and its metabolite allopregnanolone differentially regulate hemostatic proteins
after traumatic brain injury. Jacob
W VanLandingham et al.
Immediate Relevance: VERY LOW.
Link
(PDF):
http://www.nature.com/jcbfm/journal/v28/n11/pdf/jcbfm200873a.pdf
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*4. Circulating endothelial progenitor cells as a pathogenetic marker of
moyamoya disease. Keun-Hwa Jung, et al.
Immediate
Relevance:
VERY LOW.
Link (PDF): http://www.nature.com/jcbfm/journal/v28/n11/pdf/jcbfm200867a.pdf
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*5. Intravenous
grafts recapitulate the neurorestoration afforded by intracerebrally delivered
multipotent adult progenitor cells in neonatal hypoxic–ischemic rats. Takao
Yasuhara.
SULLYSUMMARY: The authors, from the
Medical College of Georgia, have published previous work demonstrating the
Creamy Goodness of transplanting multipotent allogenic progenitor cells (MAPCs)
direclty into the brains of baby rats subjected to HI insult. Here, they show
that giving the MAPCs intravenously works, for all intents and purposes, just
as well. They demonstrate that a (small) percentage of the grafted cells find
their way to the hippocampus in either event, although the number of grafted
cells retained in the brain (as identified B-gal tagging) was low. The authors
speculate--and here's the part that caught my eye--that "the major effect
of the (grafted) cells is trophic and not related to their retention in brain tissue
in significant quantity. These findings attribute recovery from ischemic injury
(in grafted animals) to the production of trophic factors mediating reduction
of inflammation and neurorestoration, as well as stimulation of
neurogenesis." An interesting paper on a hot topic.
Immediate
Relevance: Medium.
Link
(PDF): http://www.nature.com/jcbfm/journal/v28/n11/pdf/jcbfm200868a.pdf
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*6. Induction
of cerebral arteriogenesis leads to early-phase expression of protease
inhibitors in growing collaterals of the brain. Philipp Hillmeister, et al.
Immediate
Relevance: VERY
LOW.
Link (PDF): http://www.nature.com/jcbfm/journal/v28/n11/pdf/jcbfm200869a.pdf
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*7.
Estradiol attenuates neuroprotective benefits of isoflurane preconditioning in
ischemic mouse brain. Lan Wang, et al.
SULLYSUMMARY: I have to say, I was
not aware of this phenomenon of "isoflurane preconditioning." It is a
male-specific phenomenon, and the authors were interested in whether estradiol
alters ischemic outcome in isoflurance preceonditioned brain. I'll leave the
methods and all to you if you're really interested, and merely sum up by saying
that they found estradiol depresses the brain’s protective response to
isoflurane preconditiona, and that estradiol probably (surprise!) exacerbates
cortical injury through its receptor. I include the paper this month only
because of questions that have arisen vis-a-vis our switch to isoflurane and
apparent delays in cytochrome c release. It might be interesting, if this holds
up, to compare male and female cytochrome c release with isoflurane. As if we
had time.
Immediate
Relevance: Medium-HIGH
Link (PDF): http://www.nature.com/jcbfm/journal/v28/n11/pdf/jcbfm200870a.pdf
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*8.
Metabolic challenge to glia activates an adenosine-mediated safety mechanism
that promotes neuronal survival by delaying the onset of spreading depression
waves. Santiago Canals.
Immediate
Relevance:
LOW.
Link
(PDF): http://www.nature.com/jcbfm/journal/v28/n11/pdf/jcbfm200871a.pdf
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*9. Roscovitine reduces neuronal loss, glial activation, and neurologic
deficits after brain trauma. Genell
D Hilton.
SULLYSUMMARY: Basically, the Immediate
Relevance of this one is that Anthony and I are starting to look hard at TBI
models. Take a look if you're interested; I'm just getting started with it.
Immediate
Relevance: LOW-MEDIUM
Link
(PDF): http://www.nature.com/jcbfm/journal/v28/n11/pdf/jcbfm200875a.pdf
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*10. Genomic
profiles of damage and protection in human intracerebral hemorrhage. S Thomas Carmichael et al.
Immediate
Relevance:
VERY LOW
Link
(PDF): http://www.nature.com/jcbfm/journal/v28/n11/pdf/jcbfm200877a.pdf
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END
SUMMARY.