Don't bet on it. We'll have more to say about oxidative as we go on. Suffice to say, for now, that ROS generation is a very early and destructive feature of brain ischemia and reperfusion, with the potential to inflict damage throughout the cell. What's more, treatments directed at the amelioration of oxidative stress have consistently failed to improve outcome in clinical trials, which underscores something you already know by now: oxidative stress isn't the only culprit.

Which brings us to the next Horseman.