Work went pretty quickly after that, and by 1965 the genetic code was in hand. It is reproduced for your fun and amazement in Table 1. The table is easy to read. If you want to find out which three nucleotides code for, say, phenylalanine, you locate pheylalanine on the table (upper left corner). Read the first nucleotide from the left colum, the second from the top row, and the third from the right column. You should come up with UUU (Nirenberg and Matthaei did). Molecular biologists say that UUU is a codon for phenlyalanine.

second letter

FIRST LETTER

U

C

A

G

THIRD LETTER

U

Phenylalanine
Phenylalanine
Leucine
Leucine

Serine
Serine
Serine
Serine

Tyrosine
Tyrosine
Stop
Stop

Cysteine
Cysteine
Stop
Tryptophan

U
C
A
G

C

Leucine
Leucine
Leucine
Leucine

Proline
Proline
Proline
Proline

Histidine
Histidine
Glutamine
Glutamine

Arginine
Arginine
Arginine
Arginine

U
C
A
G

A

Isoleucine
Isoleucine
Isoleucine
Methionine

Threonine
Threonine
Threonine
Threonine

Asparagine
Asparagine
Lysine
Lysine

Serine
Serine
Arginine
Arginine

U
C
A
G

G

Valine
Valine
Valine
Valine

Alanine
Alanine
Alanine
Alanine

Aspartic
Aspartic
Glutamate
Glutamate

Glycine
Glycine
Glycine
Glycine

U
C
A
G

Table 1. The Genetic Code. It's easy to read if you follow the directions in the text.